Filter Results
Select filters to focus the result set. The result set changes dynamically as filters are applied or cleared.
Rule of 5 Filter Preset
When switched ON, the Rule of 5 Filter Preset sets 8 different Druglikeness and ADME filters to predetermined values based on Lipinski's rule of 5:
"...a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans."
| Druglikeness Preset | Minimum | Maximum |
| Hydrogen Bond Acceptors | — | 10 |
| Hydrogen Bond Donors | — | 5 |
| Freely Rotatable Bonds | — | 10 |
| Molecular Weight (g/mol) | — | 500 |
| Molar Refractivity (m3/mol) | 40 | 130 |
| Number of Atoms | 20 | 70 |
| ADME Preset | Minimum | Maximum |
| Partition Coefficient (logP) | — | 5 |
| Polar Surface Area (PSA) (Å2) | — | 140 |
Notes:
- Switching the preset OFF resets the Druglikeness and ADME filters.
- While the preset is ON, any adjustments made to the Druglikeness and ADME filters switches off the preset, but does not reset the values.
View Scaffold Details
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